Journal article

Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study

S Oostermeijer, S Whittle, C Suo, NB Allen, JG Simmons, N Vijayakumar, PM van de Ven, LMC Jansen, M Yucel, A Popma

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2016

Abstract

Multiple cross-sectional imaging studies have identified structural abnormalities in prefrontal, temporal and limbic regions related to conduct problems (CPs). However, the relationship between development of such neurobiological deficits and developmental pathways of CPs has remained unclear. The current study investigated distinct trajectories of CP and related trajectories of cortical thickness within a community-based sample of adolescents (n=239), age range 12-19, to address this gap. Three trajectory classes were revealed using latent class growth analyses (LCGAs), comprising a 'desisting' CP group, an 'intermediate' CP group and a 'stable low' CP group. Structural magnetic resonance i..

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Grants

Awarded by NWO/National Initiative Brain and Cognition


Awarded by Netherlands Foundation for Mental Health


Awarded by Foundation 'De Drie Lichten' in the Netherlands


Awarded by National Health and Medical Research Council of Australia


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

This study was funded by the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant 350241), the Australian Research Council (ARC; Discovery Grants DP0878136 and DP109 2637), the University of Melbourne, Sanne Oostermeijer was supported by the NWO/National Initiative Brain and Cognition (grant 056-24-014) and the Netherlands Foundation for Mental Health (grant 2008-6347) and the Foundation 'De Drie Lichten' (06/14) in the Netherlands. MY was supported by a fellowship from the National Health and Medical Research Council of Australia (APP1021973) and SW was supported by an NHMRC Career Development Fellowship (ID: 1007716).