Journal article
Whole-brain metallomic analysis of the common marmoset (: Callithrix jacchus)
B Knauer, P Majka, KJ Watkins, AWR Taylor, D Malamanova, B Paul, HH Yu, AI Bush, DJ Hare, DH Reser
Metallomics | ROYAL SOC CHEMISTRY | Published : 2017
DOI: 10.1039/c7mt00012j
Abstract
Despite the importance of transition metals for normal brain function, relatively little is known about the distribution of these elemental species across the different tissue compartments of the primate brain. In this study, we employed laser ablation-inductively coupled plasma-mass spectrometry on PFA-fixed brain sections obtained from two adult common marmosets. Concurrent cytoarchitectonic, myeloarchitectonic, and chemoarchitectonic measurements allowed for identification of the major neocortical, archaecortical, and subcortical divisions of the brain, and precise localisation of iron, manganese, and zinc concentrations within each division. Major findings across tissue compartments incl..
View full abstractGrants
Awarded by NHMRC
Awarded by Ruhr University Bochum, Research School PLUS - Germany's Excellence Initiative
Awarded by ARC Linkage Project
Awarded by NHMRC Career Development Fellowship
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
Funding Acknowledgements
The authors thank Prof. Marcello Rosa, and Drs Elizabeth Zavitz, Maureen Hagen, Nicholas Price, and Leo Lui for sharing tissues from their electrophysiological experiments. Dr Zavitz andMsMaree Reser provided helpful comments and proofreading of the manuscript prior to submission. Supported by: NHMRC Project Grant 1068140 (DHR); Ruhr University Bochum, Research School PLUS funded by Germany's Excellence Initiative [DFG GSC 98/3] (BK); ARC Linkage Project LP120200089 (DJH); Ramaciotti Foundation Establishment Grant (DJH); NHMRC Career Development Fellowship APP1122981 (DJH). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.