Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

PC Haycock; S Burgess; A Nounu; J Zheng; GN Okoli; J Bowden; KH Wade; NJ Timpson; DM Evans; P Willeit; A Aviv; TR Gaunt; G Hemani; M Mangino; HP Ellis; KM Kurian; KA Pooley; RA Eeles; JE Lee; S Fang; WV Chen; MH Law; LM Bowdler; MM Iles; Q Yang; BB Worrall; HS Markus; RJ Hung; CI Amos; AB Spurdle; DJ Thompson; TA O'Mara; B Wolpin; L Amundadottir; R Stolzenberg-Solomon; A Trichopoulou; NC Onland-Moret; E Lund; EJ Duell; F Canzian; G Severi; K Overvad; MJ Gunter; R Tumino; U Svenson; A Van Rij; AF Baas; MJ Bown; NJ Samani; FNG Van t'Hof; G Tromp; GT Jones; H Kuivaniemi; JR Elmore; M Johansson; J Mckay; G Scelo; R Carreras-Torres; V Gaborieau; P Brennan; PM Bracci; RE Neale; SH Olson; S Gallinger; D Li; GM Petersen; HA Risch; AP Klein; J Han; CC Abnet; ND Freedman; PR Taylor; JM Maris; KK Aben; LA Kiemeney; SH Vermeulen; JK Wiencke; KM Walsh; M Wrensch; T Rice; C Turnbull; K Litchfield; L Paternoster; M Standl; GR Abecasis; JP SanGiovanni; Y Li; V Mijatovic; Y Sapkota; SK Low; KT Zondervan; GW Montgomery; DR Nyholt; DA Van Heel; K Hunt; DE Arking; FN Ashar; N Sotoodehnia; D Woo; J Rosand

Journal article

Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

PC Haycock, S Burgess, A Nounu, J Zheng, GN Okoli, J Bowden, KH Wade, NJ Timpson, DM Evans, P Willeit, A Aviv, TR Gaunt, G Hemani, M Mangino, HP Ellis, KM Kurian, KA Pooley, RA Eeles, JE Lee, S Fang Show all

JAMA Oncology | Published : 2017

DOI: 10.1001/jamaoncol.2016.5945

Abstract

IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis o..

View full abstract

University of Melbourne Researchers

Qiong Yang Author

Grants

Awarded by University of Maryland, Baltimore County

Funding Acknowledgements

This work was supported by CRUK grant number C18281/A19169 (the Integrative Cancer Epidemiology Programme). Dr Haycock is supported by CRUK Population Research Postdoctoral Fellowship C52724/A20138. The MRC Integrative Epidemiology Unit is supported by grants MC_UU_12013/1 and MC_UU_12013/2. Dr Martin is supported by the National Institute for Health Research (NIHR), the Bristol Nutritional Biomedical Research Unit and the University of Bristol. Dr Timpson is supported by Medical Research Council MC_UU_12013/3.