Journal article

Human ventromedial prefrontal cortex and the positive affective processing of safety signals

Ben J Harrison, Miguel Angel Fullana, Esther Via, Carles Soriano-Mas, Bram Vervliet, Ignacio Martinez-Zalacain, Jesus Pujol, Christopher G Davey, Tilo Kircher, Benjamin Straube, Narcis Cardoner

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

Abstract

Human functional magnetic resonance imaging (fMRI) studies suggest that the ventromedial prefrontal cortex (vmPFC) contributes to the learned discrimination of threat and safety signals, although its precise contribution to these processes remains unclear. One hypothesis is that the vmPFC supports the positive affective processing of safety signals linked to their implicit stress-relieving properties. We set out to test this hypothesis and to examine the specificity of vmPFC responses to safety signal processing versus its high level of 'default mode' activity. Sixty participants completed an fMRI conditioning task that involved the generation of a conditioned threat (CS+) and safety (CS-) s..

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Grants

Awarded by Institute de Salud, Carlos III, Gobierno de Espaiia


Awarded by LIIRA Program Grant


Awarded by National Health and Medical Research Council of Australia (NHMRC) Project Grant


Awarded by Clinical Career Development Fellowship



Funding Acknowledgements

This study was funded by Institute de Salud, Carlos III, Gobierno de Espaiia. Project Grants PI12/0136 to NC and PI12/00273 to MF; LIIRA Program Grant WS717052 to NC; National Health and Medical Research Council of Australia (NHMRC) Project Grant 1025619 and Clinical Career Development Fellowship (1124472) to BJH; Instituto de Salud, Carlos III, Gobierno de Espana 'Miguel Servet' Contract and grant CP10/00604 to CSM.