Journal article
The galanin-3 receptor antagonist, SNAP 37889, suppresses alcohol drinking and morphine self-administration in mice
KJ Scheller, SJ Williams, AJ Lawrence, E Djouma
Neuropharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Abstract
The neuropeptide, galanin, is widely expressed in the central and peripheral nervous systems and is involved in a range of different functions including nociception, neurogenesis, hormone release, reproduction, cognitive function and appetite. Given the overlap between galanin expression and reward circuitry in the brain, galanin has been targeted for alcohol use disorder (AUD) and opioid dependency. Furthermore, the galanin-3 receptor (GAL3) specifically regulates emotional states and plays a role in motivation, reward and drug-seeking behaviour. We have previously shown that the GAL3 antagonist, SNAP 37889, reduces ethanol self-administration and cue-induced re-instatement in alcohol-prefe..
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Funding Acknowledgements
We thank Dr Bradley Turner for the use of his rotarod and Dr Jhodie Duncan for the use of equipment for the liver assays (The Florey Institute of Neuroscience and Mental Health). This work was funded by the Research Focus Area, Understanding Disease at La Trobe University (awarded to ED) and the Victorian State Government Infrastructure Program. KJS was supported by a La Trobe Postgraduate Scholarship and School of Life Science Postgraduate Publication Award.