Monitoring treatment of acute kidney injury with damage biomarkers
TJ Pianta, L Succar, T Davidson, NA Buckley, ZH Endre
Toxicology Letters | ELSEVIER IRELAND LTD | Published : 2017
BACKGROUND: Damage biomarkers may identify mechanisms and sites of acute kidney injury (AKI). However, the utility of novel AKI biomarkers differs by context, and their utility for monitoring treatment of AKI is unknown. We hypothesized that selected AKI biomarkers would facilitate monitoring of mechanism-specific treatment. We examined this using a panel of biomarkers to monitor cisplatin-induced AKI treatment with alpha-lipoic acid (α-LA) that has previously been demonstrated to ameliorate cisplatin induced AKI. METHODS: AKI was induced in male Sprague Dawley rats using cisplatin (6mg/kg) in the presence or absence of a single dose of α-LA (100mg/kg). A panel of 12 urinary kidney damage bi..View full abstract
Awarded by Medical Research Council
Funding for this study included Australian National Health and Medical Research Council project grant 1011772 and in-kind technical support from the Kids Research Institute at the Children's Hospital at Westmead NSW, and the Biological Resources Centre, UNSW. TJP gratefully acknowledges the financial support of the Jacquot Research Entry Scholarship and a UNSW Australian Postgraduate Award.