Journal article
Testicular growth and spermatogenesis: new goals for pubertal hormone replacement in boys with hypogonadotropic hypogonadism? -a multicentre prospective study of hCG/rFSH treatment outcomes during adolescence-
J Rohayem, BP Hauffa, M Zacharin, S Kliesch, M Zitzmann, A Wüsthof, B Tittel, M Morlot, W Vorhoff, E Müller-Rossberg, V Wagner, K Konrad, K Salzgeber, S Fricke-Otto, J Wölfle, P Willig, B Karges, E Lankes, M Droste, A Richter-Unruh Show all
Clinical Endocrinology | WILEY | Published : 2017
DOI: 10.1111/cen.13164
Abstract
Context/objective: Testosterone treatment for pubertal induction in boys with hypogonadotropic hypogonadism (HH) provides virilization, but does not induce testicular growth or fertility. Larger studies evaluating the outcomes of gonadotropin replacement during adolescence have not been reported to date; whether previous testosterone substitution affects testicular responses is unresolved. We aimed to assess the effects of human chorionic gonadotropin (hCG) and recombinant FSH (rFSH) in boys and adolescents with HH with respect to a) testicular growth, b) spermatogenesis, c) quality of life (QoL) and to identify factors influencing therapeutic success. Design/setting: A prospective case stud..
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