Journal article
Secondary Breast Cancer Risk by Radiation Volume in Women With Hodgkin Lymphoma
JL Conway, JM Connors, S Tyldesley, KJ Savage, BA Campbell, YY Zheng, J Hamm, T Pickles
International Journal of Radiation Oncology Biology Physics | ELSEVIER SCIENCE INC | Published : 2017
Abstract
Purpose To determine whether the risk of secondary breast cancer (SBC) is reduced in women with Hodgkin lymphoma (HL) treated with smaller field radiation therapy (SFRT) versus mantle field radiation therapy (MRT). Methods and Materials We used the BC Cancer Agency (BCCA) Lymphoid Cancer Database to identify female patients treated for HL between January 1961 and December 2009. Radiation therapy volumes were categorized as MRT or SFRT, which included involved field, involved site, or involved nodal radiation therapy. SBC risk estimates were compared using competing risk analysis and Fine and Gray multivariable model: MRT ± chemotherapy, SFRT ± chemotherapy, or chemotherapy-only. Results Of 7..
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Funding Acknowledgements
Supported in part by Program Project Grants from the Terry Fox Research Institute (J.M.C.), Genome Canada (J.M.C.), Genome British Columbia (J.M.C.), the Canadian Institutes for Health Research (J.M.C.), and the British Columbia Cancer Foundation (J.M.C., K.J.S., Y.Y.Z.).