Food Challenge and Community-Reported Reaction Profiles in Food-Allergic Children Aged 1 and 4 Years: A Population-Based Study
Joshua CK Chan, Rachel L Peters, Jennifer J Koplin, Shyamali C Dharmage, Lyle C Gurrin, Melissa Wake, Mimi LK Tang, Susan Prescott, Katrina J Allen
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | ELSEVIER SCIENCE BV | Published : 2017
BACKGROUND: Oral food challenge is the main tool for diagnosing food allergy, but there is little data on the reaction profiles of young children undergoing challenges, nor how these reactions compare to reactions on accidental ingestion in the community. OBJECTIVES: To compare reaction profiles from food challenges and parent-reported reactions on accidental ingestion, and assess predictors of severe reactions. METHODS: HealthNuts is a longitudinal population-based cohort study of 5276 1-year-old infants. Infants underwent skin prick tests and those with identifiable wheals were offered food challenges. Food challenges were repeated at age 4 years in those with previous food allergy or repo..View full abstract
This work was supported by funding from the National Health & Medical Research Council (NHMRC) of Australia, Ilhan Food Allergy Foundation, AnaphylaxiStop, the Charles and Sylvia Viertel Medical Research Foundation, the Victorian Government's Operational Infrastructure Support Program, and the NHMRC Centre for Food and Allergy Research. J.C.K.C. is a recipient of the Hong Kong Innovation and Technology Scholarship.