Journal article

Fatty acid composition of the postmortem corpus callosum of patients with schizophrenia, bipolar disorder, or major depressive disorder

K Hamazaki, M Maekawa, T Toyota, B Dean, T Hamazaki, T Yoshikawa

European Psychiatry | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2017

Abstract

BACKGROUND: Studies investigating the relationship between n-3 polyunsaturated fatty acid (PUFA) levels and psychiatric disorders have thus far focused mainly on analyzing gray matter, rather than white matter, in the postmortem brain. In this study, we investigated whether PUFA levels showed abnormalities in the corpus callosum, the largest area of white matter, in the postmortem brain tissue of patients with schizophrenia, bipolar disorder, or major depressive disorder. METHODS: Fatty acids in the phospholipids of the postmortem corpus callosum were evaluated by thin-layer chromatography and gas chromatography. Specimens were evaluated for patients with schizophrenia (n=15), bipolar disord..

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Grants


Awarded by Grants-in-Aid for Scientific Research


Funding Acknowledgements

this work was supported by a Grant-in-Aid for Scientific Research (C) (25461726), Japan. BD is a National Health and Medical Research Council Senior Research Fellow (APP1002240). This work was supported in part by the Victorian Government's Operational Infrastructure Support. The funding sources had no role in the study design; the collection, analysis, and interpretation of data; writing the report; or the decision to submit the paper for publication.