Journal article
Mitochondrial mutations and metabolic adaptation in pancreatic cancer
Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders
CANCER & METABOLISM | BMC | Published : 2017
Abstract
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy for cancers such as pancreatic cancer, which are driven by genetic alterations that are not tractable drug targets. Although somatic mitochondrial genome (mtDNA) mutations have been observed in various tumors types, understanding of metabolic genotype-phenotype relationships is limited. METHODS: We deployed an integrated approach combining genomics, metabolomics, and phenotypic analysis on a unique cohort of patient-derived pancreatic cancer cell lines (PDCLs). Genome ..
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Grants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by New South Wales Office of Science and Medical Research, Cancer Institute New South Wales
Awarded by Cancer Council NSW
Awarded by MRC
Funding Acknowledgements
This research was supported by funding from the National Health and Medical Research Council of Australia (NHMRC 1052963, 631701, 535903, 427601); Mostyn Family Foundation; Patricia Helen Guest Fellowship; New South Wales Office of Science and Medical Research, Cancer Institute New South Wales (09/CDF/2-39, 10/ECF/2-26; 10/CRF/1-01, 08/RSA/1-15, 07/CDF/ 1-28, 10/FRL/2-03, 06/RSA/1-05, 09/RIG/1-02, 10/TPG/1-04, 11/REG/1-10, 11/ CDF/3-26); University of NSW; University of Sydney; Beth Yarrow Memorial Award in Medical Science; Australian Research Council (ARC) Future Fellowship; Australian Government Department of Innovation, Industry, Science and Research (DIISR); Australian Cancer Research Foundation (ACRF); Queensland Government (NIRAP); University of Queensland; Cancer Council NSW (SRP06-01); Philip Hemstritch Foundation.