Journal article

ANALYSIS OF THE OUTCOME OF INVITRO FERTILIZATION IN RELATION TO THE TIMING OF HUMAN CHORIONIC-GONADOTROPIN ADMINISTRATION BY THE DURATION OF ESTRADIOL RISE IN STIMULATED CYCLES

D LEVRAN, A LOPATA, PL NAYUDU, MJ MARTIN, JC MCBAIN, CM BAYLY, AL SPEIRS, WIH JOHNSTON

FERTILITY AND STERILITY | AMER SOC REPRODUCTIVE MEDICINE | Published : 1985

Abstract

A retrospective analysis was carried out to assess the outcome of ovarian stimulation on in vitro fertilization when human chorionic gonadotropin (hCG) was administered after 5, 6, or 7 days of continuously rising plasma estradiol (E2). There was no significant difference in the number and size of large follicles in each group although the number of small follicles (less than 15 mm in diameter) decreased significantly after 7 days of E2 rise. After hCG injection in the 7-day group, the E2 level fell below the previous day's value in 40% of patients, whereas a similar fall was observed in only 16% of patients in the 5- and 6-day groups. In those cycles where a luteinizing hormone surge occurr..

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