The outcomes of pancreaticoduodenectomy in patients aged 80 or older: a systematic review and meta-analysis

Abstract

Background There is an increasing needed to consider pancreaticoduodenectomy (PD) for the treatment of pancreatic and periampullary malignancy in patients aged 80 and over, given the increasing aging population. Methods A systematic literature search was undertaken to identify selected studies that compared the outcomes of patients aged 80 years or over to those younger undergoing PD. Results In total 18 studies were included for evaluation. Octogenarian or older populations had significantly higher 30-day post-operative mortality rate (OR: 2.22, 95% CI = 1.48–3.31, p < 0.001) and length of hospital stay (OR: 2.23, 95% CI = 1.36–3.10, p < 0.001). The overall post-operative complication rate ..