7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution

PE Yoo; SE John; S Farquharson; JO Cleary; YT Wong; A Ng; CB Mulcahy; DB Grayden; RJ Ordidge; NL Opie; TJ O'Brien; TJ Oxley; BA Moffat

Journal article

7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution

PE Yoo, SE John, S Farquharson, JO Cleary, YT Wong, A Ng, CB Mulcahy, DB Grayden, RJ Ordidge, NL Opie, TJ O'Brien, TJ Oxley, BA Moffat

Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018

DOI: 10.1016/j.neuroimage.2017.03.002

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Abstract

Recent developments in accelerated imaging methods allow faster acquisition of high spatial resolution images. This could improve the applications of functional magnetic resonance imaging at 7 Tesla (7T-fMRI), such as neurosurgical planning and Brain Computer Interfaces (BCIs). However, increasing the spatial and temporal resolution will both lead to signal-to-noise ratio (SNR) losses due to decreased net magnetization per voxel and T1-relaxation effect, respectively. This could potentially offset the SNR efficiency gains made with increasing temporal resolution. We investigated the effects of varying spatial and temporal resolution on fMRI sensitivity measures and their implications on fMRI..

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Funding Acknowledgements

Funding: This work was supported by US Defense Advanced Research Projects Agency (DARPA), the Office of Naval Research (ONR) Global N62909-14-1-N020, National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532, Melbourne Neuroscience Institute (MNI), National Imaging Facility (NIF), Defence Health Foundation, Australia (Booster Grant), and the author J. O. C was funded by the University of Melbourne McKenzie Fellowship.