Journal article

Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial

Celene YL Yap, David McD Taylor, Jonathan C Knott, Simone E Taylor, Georgina A Phillips, Jonathan Karro, Esther W Chan, David CM Kong, David J Castle

ADDICTION | WILEY | Published : 2017


AIM: To examine the efficacy and safety of (1) midazolam-droperidol versus droperidol and (2) midazolam-droperidol versus olanzapine for methamphetamine-related acute agitation. DESIGN AND SETTING: A multi-centre, randomized, double-blind, controlled, clinical trial was conducted in two Australian emergency departments, between October 2014 and September 2015. PARTICIPANTS: Three hundred and sixty-one patients, aged 18-65 years, requiring intravenous medication sedation for acute agitation, were enrolled into this study. We report the results of a subgroup of 92 methamphetamine-affected patients. INTERVENTION AND COMPARATOR: Patients were assigned randomly to receive either an intravenous bo..

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Funding Acknowledgements

The authors would like to acknowledge the cooperation provided by the staff of the participating emergency departments, without whose assistance this study could not have been undertaken. We also acknowledge Dr Wee Leng Lee for his assistance in study pack preparation. The study was supported financially by the Morson Taylor Research Award 2013 of the Australasian College for Emergency Medicine Foundation and The Austin Medical Research Foundation, 2014. Neither organization had any role in the design or execution of the study, data analysis or interpretation.