Synthesis of Mn(II) and Zn(II) complexes with new macrocyclic Schiff-base ligands containing piperazine moiety: Spectroscopic, structural, cytotoxic and antibacterial properties

Abstract

The new diamine 2,2′-(piperazine-1,4-diylbis(methylene))dianiline (A1) was synthesized by reaction of 2-nitrobenzylchloride and piperazine. Its corresponding Mn(II) and Zn(II) macrocyclic Schiff-base complexes were prepared via the metal templated [1+1] cyclocondensation of this diamine and 2,6-diacetylpyridine or 2,6-pyridinedicarbaldehyde. The diamine and all the macrocyclic complexes were characterized by elemental analysis, mass spectrometry and spectroscopic methods such as: FT-IR, 1H and 13C NMR. Also, the crystal structures of [MnL1(ClO4)2] (1) and [ZnL1(H2O)2](ClO4)2 (3) complexes were obtained by single-crystal X-ray crystallography. The cytotoxic properties of all macrocyclic compl..