Journal article
The performance of human papillomavirus biomarkers in predicting anal high-grade squamous intraepithelial lesions in gay and bisexual men
F Jin, JM Roberts, AE Grulich, IM Poynten, DA MacHalek, A Cornall, S Phillips, D Ekman, RL McDonald, RJ Hillman, DJ Templeton, A Farnsworth, SM Garland, CK Fairley, SN Tabrizi, C Law, C Biro, A Richards, J Thurloe, M Adams Show all
AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Background: We evaluate the performance of human papillomavirus (HPV) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions in gay and bisexual men (GBM) in Sydney, Australia. Design: Baseline analysis of a 3-year cohort study. Methods: The Study of the Prevention of Anal Cancer is natural history study of anal HPV infection in GBM aged at least 35 years. All participants completed cytological and histological assessments. Stored ThinPrep PreservCyt residua were tested for HPV genotyping (Linear Array and Cobas 4800) and viral load, E6/E7 mRNA expression (NucliSENS easyQ HPV v1) and dual cytology staining of p16INK4a/Ki 67 antibodies (CINtecPLUS). Performa..
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Awarded by National Health and Medical Research Council