Journal article

Circulating gluten-specific FOXP3( )CD39( ) regulatory T cells have impaired suppressive function in patients with celiac disease

Laura Cook, C Mee Ling Munier, Nabila Seddiki, David van Bockel, Noe Ontiveros, Melinda Y Hardy, Jana K Gillies, Megan K Levings, Hugh H Reid, Jan Petersen, Jamie Rossjohn, Robert P Anderson, John J Zaunders, Jason A Tye-Din, Anthony D Kelleher

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2017

Abstract

BACKGROUND: Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although the effector T-cell response in patients with celiac disease has been well characterized, the role of regulatory T (Treg) cells in the loss of tolerance to gluten remains poorly understood. OBJECTIVE: We sought to define whether patients with celiac disease have a dysfunction or lack of gluten-specific forkhead box protein 3 (FOXP3)+ Treg cells. METHODS: Treated patients with celiac disease underwent oral wheat challenge to stimulate recirculation of gluten-specific T cells. Peripheral blood was collected before and after challenge. To comprehensively measure the glu..

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Grants

Awarded by NHMRC


Awarded by Australian Research Council Australia Laureate Fellowship


Awarded by National Health and Medical Research Council


Funding Acknowledgements

Supported by the Australian Government Department of Health and Ageing; the NHMRC through a program (510448) grant, NHMRC project grant (1085875), an Australian Research Council Australia Laureate Fellowship (FL160100049) (to J.R.), and a Practitioner Fellowship (to A. D.K.); a Coeliac Research Fund Grant (to N.S., R.P.A., J.T.-D., and A. D.K.); an Australian Postgraduate Award; and a UNSW Research Excellence Scholarship (to L.C.). H.H.R. has received a grant from the National Health and Medical Research Council (1085875).