Journal article
A 'Disease Severity Index' to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia
D Ferreira, F Falahati, C Linden, RF Buckley, KA Ellis, G Savage, VL Villemagne, CC Rowe, D Ames, A Simmons, E Westman
Scientific Reports | NATURE PORTFOLIO | Published : 2017
DOI: 10.1038/srep44368
Abstract
Subjective memory decline (SMD) is a heterogeneous condition. While SMD might be the earliest sign of Alzheimer's disease (AD), it also occurs in aging and various neurological, medical, and psychiatric conditions. Identifying those with higher risk to develop dementia is thus a major challenge. We tested a novel disease severity index generated by multivariate data analysis with numerous structural MRI measures as input. The index was used to identify SMD individuals with high risk of progression to mild cognitive impairment (MCI) or AD. A total of 69 healthy controls, 86 SMD, 45 MCI, and 38 AD patients were included. Subjects were followed up for 7.5 years. Clinical, cognitive, PET amyloid..
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Funding Acknowledgements
This project is financially supported by the Swedish Foundation for Strategic Research (SSF). The authors also thank the Strategic Research Programme in Neuroscience at Karolinska Institutet (StratNeuro), the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet, Hjarnfonden, Alzheimerfonden, Stiftelsen for alderssjukdomar vid Karolinska Institutet, Birgitta och Sten Westerberg, Gamla Tjanarinnor and Demensforbundet for additional financial support. The AIBL study (www.AIBL.csiro.au) is a collaboration between CSIRO, Edith Cowan University (ECU), The Florey Institute of Neuroscience and Mental Health (FINMH), National Ageing Research Institute (NARI) and Austin Health. AIBL involves support from CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study received funding support from CSIRO, the Science and Industry Endowment Fund (www.SIEF.org.au), NHMRC and Dementia Collaborative Research Centres (DCRC), Alzheimer's Australia (AA), Alzheimer's Association and the McCusker Alzheimer's Research Foundation. The above-mentioned funding sources had no involvement in the study design, collection, analysis and interpretation of the data, writing of the report and the decision to submit the article for publication.