The cell surface mucin MUC1 limits the severity of influenza A virus infection

JL McAuley; L Corcilius; H-X Tan; RJ Payne; MA McGuckin; LE Brown

Journal article

The cell surface mucin MUC1 limits the severity of influenza A virus infection

JL McAuley, L Corcilius, H-X Tan, RJ Payne, MA McGuckin, LE Brown

Mucosal Immunology | NATURE PUBLISHING GROUP | Published : 2017

DOI: 10.1038/mi.2017.16

University of Melbourne Researchers

Julie McAuley Author Microbiology and Immunology

Mike McGuckin Author Medicine, Dentistry and Health Sciences

Lorena Brown Author Microbiology and Immunology

Hyon Xhi Tan Author Microbiology and Immunology

Related Projects (1)

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Awarded by Australian Research Council

Funding Acknowledgements

J.M. is funded by the National Health and Medical Research Council of Australia (NHMRC) Project Grant 1079924; H.X.T. receives the Australian Postgraduate Award for PhD salary support. L.B. receives funding from NHMRC Program Grant 1071916. R.P. acknowledges the Australian Research Council for Discovery Project funding (DP120100194). L.C. also acknowledges John A. Lamberton Scholarship for PhD funding. M.M. is supported by a Senior Research Fellowships from the NHMRC. We acknowledge St Jude Children's Research Hospital, (TN, USA) as the original source of the PR8 plasmids used to reverse engineer and generate the IAV used in this study. We also acknowledge the Biological Optical Microscopy Platform at the University of Melbourne for use and maintenance of the confocal microscopy suite.