Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age
Adrian J Lowe, Bianca Angelica, John Su, Caroline J Lodge, David J Hill, Bircan Erbas, Catherine M Bennett, Lyle C Gurrin, Christine Axelrad, Michael J Abramson, Katrina J Allen, Shyamali C Dharmage
Pediatric Allergy and Immunology | WILEY | Published : 2017
BACKGROUND: Few studies have simultaneously addressed the importance of age of onset and persistence of eczema for the subsequent development of asthma and hay fever, particularly into early adulthood. METHODS: A high-risk birth cohort was recruited comprising 620 infants, who were then followed up frequently until 2 years of age, annually from age 3 to 7, then at 12 and 18 years, to document any episodes of eczema, current asthma, and hay fever. The generalized estimation equation technique was used to examine asthma and hay fever outcomes at 6 (n = 325), 12 (n = 248) and 18 (n = 240) years, when there was consistency of associations across the follow-ups. RESULTS: Very early-onset persiste..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Nestec Ltd, a subsidiary of Nestle Australia, provided staff funding for the first 6 years of the study, Asthma Foundation of Victoria supported the 12-year follow-up, while the National Health and Medical Research Council of Australia (NHMRC) funded the 18-year follow-up (APP454856). A.J.L., C. J. L., K.J.A., and S.C.D. are supported by the National Health and Medical Research Council of Australia.