The association of time and medications with changes in bone mineral density in the 2 years after critical illness
Neil R Orford, Michael Bailey, Rinaldo Bellomo, Julie A Pasco, Claire Cattigan, Tania Elderkin, Sharon L Brennan-Olsen, David J Cooper, Mark A Kotowicz
CRITICAL CARE | BMC | Published : 2017
BACKGROUND: Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and time remain unexplored. The objective of this study was to describe the association of time after ICU admission, and post-ICU administration of bone anti-fracture therapy or glucocorticoids after critical illness, with change in BMD. METHODS: In this prospective observational study, conducted in a tertiary hospital ICU, we studied adult patients requiring mechanical ventilation for at least 24 hours and measured BMD annually for 2 years after ICU discharge. We performed mixe..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship
This study was supported by an unrestricted grant from the Intensive Care Foundation. SBO is supported by a National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship (1107510).