Journal article
An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event
P Tettey, S Simpson, BV Taylor, AL Ponsonby, RM Lucas, T Dwyer, K Kostner, K Dear, I Van Der Mei, L Blizzard, S Broadley, T Kilpatrick, D Williams, J Lechner-Scott, C Shaw, C Chapman, A Coulthard, P Valery
Journal of Neurology Neurosurgery and Psychiatry | BMJ PUBLISHING GROUP | Published : 2017
Abstract
Objective: To investigate the prospective associations between adiposity and lipid-related variables and conversion to multiple sclerosis (MS), time to subsequent relapse and progression in disability. Methods: A cohort of 279 participants with a first clinical diagnosis of central nervous system demyelination was prospectively followed to 5-year review. Height, weight, waist and hip circumference were measured, and serum samples taken for measurement of lipids and apolipoproteins. Survival analysis was used for conversion to MS and time to relapse, and linear regression for annualised change in disability (Expanded Disability Status Scale). Results: Higher body mass index (BMI; adjusted HR ..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The AusLong Study was funded by a grant from the Australian National Health and Medical Research Council (NHMRC APP544922)