Journal article
Modulation of retinal arteriolar central reflection by APOE genotype
S Frost, A Bhuiyan, D Offerman, JD Doecke, SL Macaulay, HR Sohrabi, D Ames, C Masters, RN Martins, Y Kanagasingam
Current Alzheimer Research | BENTHAM SCIENCE PUBL LTD | Published : 2017
Abstract
Objective: This study investigated the retinal arteriolar central reflex (CR, the central reflection observed in photographs of retinal vessels), which may provide information about micro-vascular health in the retina and also the brain, due to the homology between these vascular networks. The study also describes a novel computer based semi-automated technique that accurately quantifies retinal arteriolar CR and vessel width, and calculates the CR to vessel width ratio (CRR) from digital retinal photographs. Methods: Digital retinal photographs were collected from participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL), including 25 participants diagnosed wit..
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Funding Acknowledgements
We thank all the participants who took part in this study and the clinicians who referred participants. The Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) study is a collaboration between CSIRO Australia, Edith Cowan University (Perth, Western Australia, Australia), The Florey Institute of Neuroscience and Mental Health (Melbourne, Victoria, Australia), National Ageing Research Institute and Austin Health (Parkville, Victoria, Australia). It also involves support from CogState Ltd. (Melbourne, Victoria, Australia), Hollywood Private Hospital and Sir Charles Gairdner Hospital (Nedlands, Western Australia, Australia). The AIBL study received funding support from the Science and Industry Endowment Fund, National Health and Medical Research Council (NHMRC) and Dementia Collaborative Research Centres (DCRC), Alzheimer's Australia and the McCusker Alzheimer's Research Foundation, as well as Industry.