Journal article

Spatiotemporal mapping of epileptic spikes using simultaneous EEG-functional MRI

Jennifer M Walz, Mangor Pedersen, Amir Omidvarnia, Mira Semmelroch, Graeme D Jackson

BRAIN | OXFORD UNIV PRESS | Published : 2017

Abstract

Epileptic spikes occur on the sub-second timescale and are known to involve not only epileptic foci but also large-scale distributed brain networks. There is likely to be a sequence of neural activity in multiple brain regions that occurs within the duration of a single spike, but standard electroencephalography-functional magnetic resonance imaging analyses, which use only the timing of the spikes to model the functional magnetic resonance imaging data, cannot determine the sequence of these activations. Our aim in this study is to temporally resolve these spatial activations to observe the spatiotemporal dynamics of the spike-related neural activity at a sub-second timescale. We studied ei..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (#628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. We also acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility (NIF) at the Florey node. G.J. is supported by an NHMRC practitioner's fellowship (#1060312) and has received honoraria from UCB, and royalties from Elsevier for Magnetic Resonance in Epilepsy 2nd ed. M.P. is supported by the University of Melbourne scholarships (MIRS & MIFRS).