Journal article

Breaking Up Prolonged Sitting Alters the Postprandial Plasma Lipidomic Profile of Adults With Type 2 Diabetes

Megan S Grace, Paddy C Dempsey, Parneet Sethi, Piyushkumar A Mundra, Natalie A Mellett, Jacquelyn M Weir, Neville Owen, David W Dunstan, Peter J Meikle, Bronwyn A Kingwell

The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2017


Context: Postprandial dysmetabolism in type 2 diabetes (T2D) is exacerbated by prolonged sitting and may trigger inflammation and oxidative stress. It is unknown what impact countermeasures to prolonged sitting have on the postprandial lipidome. Objective: In this study, we investigated the effects of regular interruptions to sitting, compared with prolonged sitting, on the postprandial plasma lipidome. Design: Randomized crossover experimental trial. Setting: Participants underwent three 7-hour conditions: uninterrupted sitting (SIT); light-intensity walking interruptions (LW); and simple resistance activity interruptions (SRA). Participants and Samples: Baseline (fasting) and 7-hour (postp..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC) Project

Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) Project Grant 1081734 and the Victorian Government Opperational Infrastructure Support scheme. P.C.D. is supported by an Australian postgraduate award and a Baker Bright Sparks top-up scholarship. B.A.K., P.J.M., N.O., and D.W.D. are supported by the NHMRC Fellowships scheme. M.S.G. is supported by a Flack Fellowship.