Journal article

Dendritic cells and T lymphocytes: Developmental and functional interactions

K Shortman, L Wu, G Suss, V Kronin, K Winkel, D Saunders, D Vremec, undefined Miller, undefined Rajewsky, undefined Carbone, undefined Mathis, undefined Metcalf, undefined Mosmann, undefined Strasser, undefined Tarlinton, undefined Goodnow, undefined Melchers, undefined Hodgkin, GR Bock (ed.), JA Goode (ed.)

MOLECULAR BASIS OF CELLULAR DEFENCE MECHANISMS | JOHN WILEY & SONS LTD | Published : 1997

Abstract

Dendritic cells (DCs) are specialized for presentation of antigen to T cells and are essential for primary T cell activation. Although DCs are generally considered to be myeloid derived, we now have evidence that a subgroup are of lymphoid origin. In particular, the DCs of the adult mouse thymus appear to be derived from the same early, lymphoid-restricted precursor cells that generate T lymphocytes. Purified early thymic T precursors have the capacity to produce T cells, B cells, NK cells and DCs, but not myeloid cells, on transfer to irradiated recipients. They also produce thymic DCs on culture with a mix of cytokines; this mix does not include GM-CSF, needed to generate myeloid-derived D..

View full abstract