Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
Abdulhadi Bima, Angela Pezic, Cong Sun, Fergus J Cameron, Christine Rodda, Ingrid van der Mei, Rachel Chiaroni-Clarke, Terence Dwyer, Andrew Kemp, Jun Qu, John Carlin, Justine A Ellis, Anne-Louise Ponsonby
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | WALTER DE GRUYTER GMBH | Published : 2017
BACKGROUND: Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood. METHODS: The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D3 and 1,25(OH)2D3 were measured by selective solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry. These concentrations were deseasonalised where relevant to remove the effect of month of sampling. RESULTS: Deseasonalised log 25(OH)D3 a..View full abstract
We acknowledge support from the Australian National Health and Medical Research Council (NHMRC), Financial Markets Foundation for Children, Diabetes Australia Research Trust, the Australian Research Council (ARC), Arthritis Australia, Rebecca L Cooper Foundation, Lew Carty Charitable Fund, ANZ Medical Research and Technologies in Victoria Fund, Lynne Quayle Charitable Trust, The Victorian State Government Operational Infrastructure Support Program, and the Murdoch Childrens Research Institute. CS was supported by a NHMRC Early Career Fellowship. ALP was supported by a NHMRC Senior Research Fellowship. JAE was supported by an ARC Future Fellowship.