Journal article

Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer.

J Southby, MW Kissin, JA Danks, JA Hayman, JM Moseley, MA Henderson, RC Bennett, TJ Martin

Cancer Res | Published : 1990


Parathyroid hormone-related protein (PTHrP) is known to be a causative factor in humoral hypercalcemia of malignancy. A polyclonal rabbit antiserum directed against the amino-terminal region of the protein and immunoperoxidase methods have been used to locate the presence of PTHrP in a series of 102 consecutive invasive breast tumors removed surgically from normocalcemic women. Positive PTHrP staining was detected in 60% of the tumors but not in the accompanying normal breast tissue. Positive staining was related to the progesterone receptor status of the tumor (P = 0.039) and to the prognostic index of the patient (P = 0.046) and not to estrogen receptor status, patient age, tumor size, his..

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