Journal article

Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia

John Wlodarczyk, Andrew E Ajani, Dante Kemp, Nick Andrianopoulos, Angela L Brennan, Stephen J Duffy, David J Clark, Christopher M Reid

HEART LUNG AND CIRCULATION | ELSEVIER SCIENCE INC | Published : 2016

Abstract

BACKGROUND: Major bleeding is a serious complication of percutaneous coronary intervention (PCI). We set out to investigate the incidence of major bleeding and its impact on hospitalisation and long-term mortality. METHOD: We examined seven years of registry data encompassing 16,860 PCI procedures. RESULTS: Between 2005 and 2011 major bleeding increased from 1.3% to 3.4%. In patients with ST elevated myocardial infarction (STEMI), the rate increased from 2.3% to 6.4%. The increase remained significant after adjusting for patient and procedural characteristics (OR=1.09/year, p=0.001). Bleeding risk was highest in patients presenting with out-of-hospital cardiac arrest and cardiogenic shock (C..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

The Melbourne Interventional Group acknowledges funding from Abbott, Astra-Zeneca, Biotronik, Boston Scientific, Bristol-Myers Squibb, Cordis Johnson & Johnson, CSL, Medtronic, MSD, Pfizer, Sanofi-Aventis, Servier, Schering-Plough and The Medicines Company. These companies do not have access to data.Dr. Duffy's work is supported by a NHMRC Program Grant to the Alfred and Baker Medical Unit. Prof Reid's work is supported a NHMRC Senior Research Fellowship and NHMRC Program Grant.