Journal article
Integrated genomic characterization of oesophageal carcinoma
J Kim, R Bowlby, AJ Mungall, AG Robertson, RD Odze, AD Cherniack, J Shih, CS Pedamallu, C Cibulskis, A Dunford, SR Meier, J Kim, J Raphael, HT Wu, AM Wong, JE Willis, AJ Bass, S Derks, K Garman, SJ McCall Show all
Nature | Published : 2017
DOI: 10.1038/nature20805
Abstract
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aet..
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Awarded by National Center for Advancing Translational Sciences
Funding Acknowledgements
We are grateful to all patients who contributed to this study, to K. Hoadley and R. Kucherlapati for scientific editing, and to J. Zhang and I. Felau for administrative support. This work was supported by the Intramural Research Program and the following grants from the United States National Institutes of Health: 5U24CA143799, 5U24CA143835, 5U24CA143840, 5U24CA143843, 5U24CA143845, 5U24CA143848, 5U24CA143858, 5U24CA143866, 5U24CA143867, 5U24CA143882, 5U24CA143883, 5U24CA144025, U54HG003067, U54HG003079, and U54HG003273, P30CA16672.