Thesis / Dissertation

Cancer risks for people with colorectal cancer-predisposing genetic mutations

A WIN, MA Jenkins (ed.), JL Hopper (ed.), JG Dowty (ed.), RJ MacInnis (ed.)

Published : 2013


Background: Colorectal cancer is one of the most frequently diagnosed cancers in the world. On average, 1 in 20 people will be diagnosed with colorectal cancer in their lifetime. However, an individual’s risk of colorectal cancer varies greatly depending on their genetic and environmental factors. One of the strongest risk factors for colorectal cancer is inherited mutations in predisposing genes such as DNA mismatch repair genes (Lynch syndrome), and DNA base excision repair gene, MUTYH. Given the availability and effectiveness of colorectal cancer screening and interventions, we need precise and accurate risks of cancers to reduce the burden of disease by targeting preventive measures to t..

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