Journal article

Endoscopic mucosal resection for large serrated lesions in comparison with adenomas: a prospective multicentre study of 2000 lesions

Maria Pellise, Nicholas G Burgess, Nicholas Tutticci, Luke F Hourigan, Simon A Zanati, Gregor J Brown, Rajvinder Singh, Stephen J Williams, Spiro C Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Heok P'Ng, Hema Mahajan, Duncan McLeod, Michael J Bourke

Gut | BMJ PUBLISHING GROUP | Published : 2017

Abstract

OBJECTIVE: Endoscopic mucosal resection (EMR) is effective for large laterally spreading flat and sessile lesions (LSLs). Sessile serrated adenomas/polyps (SSA/Ps) are linked to the relative failure of colonoscopy to prevent proximal colorectal cancer. We aimed to examine the technical success, adverse events and recurrence following EMR for large SSA/Ps in comparison with large conventional adenomas. DESIGN: Over 74 months till August 2014, prospective multicentre data of LSLs ≥20 mm were analysed. A standardised dye-based conventional EMR technique followed by scheduled surveillance colonoscopy was used. RESULTS: From a total of 2000 lesions, 323 SSA/Ps in 246 patients and 1527 adenomas in..

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University of Melbourne Researchers

Grants

Awarded by Instituto de Salud Carlos III


Funding Acknowledgements

MP was supported by a funding grant from the Societat Catalana de Digestologia and by a grant from the Instituto de Salud Carlos III (BA14/00030). NGB was supported by a funding grant from the Westmead Medical Research Foundation (WMRF). The Cancer Institute New South Wales provided funding for a research nurse and data manager to assist with the administration of the study. There was no influence from the WMRF or the Cancer Institute on study design or conduct, data collection and management, analysis, interpretation, preparation and review or approval of the manuscript.