Journal article

Functional conservation of the malaria vaccine antigen MSP-1(19) across distantly related Plasmodium species

RA O'Donnell, A Saul, AF Cowman, BS Crabb

NATURE MEDICINE | NATURE AMERICA INC | Published : 2000

Abstract

The C-terminal region of Plasmodium falciparum merozoite surface protein 1 (MSP-119) is at present a leading malaria vaccine candidate. Antibodies against the epidermal growth factor-like domains of MSP-1 19are associated with immunity to P. falciparum and active immunization with recombinant forms of the molecule protect against malaria challenge in various experimental systems. These findings, with the knowledge that epidermal growth factor-like domains in other molecules have essential binding functions, indicate the importance of this protein in merozoite invasion of red blood cells. Despite extensive molecular epidemiological investigations, only limited sequence polymorphism has been i..

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