Journal article

Repeat intracoronary radiation for recurrent in-stent restenosis in patients who failed intracoronary radiation.

Ron Waksman, Robert Lew, Andrew E Ajani, Augusto D Pichard, Lowell F Satler, Kenneth M Kent, Rosanna Chan, R Larry White, William O Suddath, Ellen Pinnow, Rebecca Torguson, Christian Dilcher, Roswitha Wolfram, Joseph Lindsay

Circulation | Published : 2003


BACKGROUND: Intracoronary radiation therapy (IRT) is the only proven treatment for in-stent restenosis (ISR). It is, however, associated with a significant failure rate. The present study evaluated the outcomes of patients who underwent repeat intracoronary radiation for recurrent ISR. METHODS AND RESULTS: Fifty-one consecutive patients who failed a previous radiation treatment, presented with angina and angiographic evidence of ISR, and were treated with percutaneous coronary intervention (PCI) and repeat radiation to the same segment were studied. Twenty-five patients were treated with gamma radiation in a dose of 15 Gy, and 26 were treated with beta radiation doses of 18.3 to 23 Gy. The m..

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