How to fix the edge effect of catheter-based radiation therapy in stented arteries.
Edouard Cheneau, Ron Waksman, Hamid Yazdi, Rosanna Chan, Jana Fourdnadjiev, Chalak Berzingi, Vivek Shah, Andrew E Ajani, Laurent Leborgne, Fermin O Tio
Circulation | Published : 2002
BACKGROUND: Edge stenosis remains a serious limitation of catheter-based vascular brachytherapy (VBT). This study aims to identify the mechanisms and evaluate strategies to minimize edge restenosis in patients treated with VBT. METHODS AND RESULTS: Thirty-four porcine stented coronary arteries were irradiated (doses of 15 or 22 Gy) with (192)Ir trains of either 6 seeds (23 mm) with 0 mm coverage at the distal stent edge and 10 mm at the proximal stent edge or 14 seeds (55 mm) centered at the distal edge of the stent with 27.5 and 14.5 mm coverage at the distal and proximal edges, respectively. After VBT, an additional 13-mm stent was positioned overlapping the distal margin of the first sten..View full abstract