Journal article

Elderly patients have a favorable outcome after intracoronary radiation for in-stent restenosis.

Andrew E Ajani, Ron Waksman, Edouard Cheneau, Dong-Hun Cha, Ellen Pinnow, Augusto D Pichard, Lowell F Satler, Kenneth M Kent, Joseph Lindsay

Catheterization and Cardiovascular Interventions | Published : 2002

Abstract

Intracoronary radiation therapy (IRT) reduces recurrent in-stent restenosis (ISR) by inhibition of smooth muscle cell proliferation. The ability of these cells to replicate is limited with age due to changes in the telomeres. The purpose of this study was to assess the effect of age on outcomes following IRT for ISR. We evaluated 1,088 patients with 6-month clinical follow-up who were enrolled in radiation trials for ISR using gamma- and beta-emitters. Patients were analyzed within and between IRT (n = 861) or placebo therapy (n = 227) in four age groups ( 75 years). Baseline characteristics were similar within each age group of IRT patients, except elderly patients (> 75 years) had a lower ..

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University of Melbourne Researchers