Impact of intracoronary radiation on in-stent restenosis involving ostial lesions.
Andrew E Ajani, Ron Waksman, Edouard Cheneau, Laurent Leborgne, Ellen Pinnow, Daniel A Canos, Lowell F Satler, Augusto D Pichard, Kenneth M Kent, Joseph Lindsay
Catheter Cardiovasc Interv | Published : 2003
The aim of this study was to compare 6-month clinical outcomes of patients with in-stent restenosis (ISR) involving the ostium treated with intracoronary radiation therapy (IRT) compared to placebo therapy, and also to nonostial lesions treated with IRT. Coronary interventions in ostial lesions have a high rate of recurrence of restenosis. The impact of IRT on ostial ISR has been inadequately characterized. We assessed patients enrolled in gamma (192-iridium) and beta (90-yttrium, 32-phosphorus) radiation trials for ISR at the Washington Hospital Center. Of patients receiving IRT, 105 (8%) patients had ostial ISR and 1,289 (92%) patients had nonostial ISR. Twenty-seven patients had ostial IS..View full abstract