Journal article

Usefulness of periprocedural creatinine phosphokinase-MB release to predict adverse outcomes after intracoronary radiation therapy for in-stent restenosis.

Andrew E Ajani, Ron Waksman, Arvind K Sharma, Robert Lew, Ellen Pinnow, Daniel A Canos, Edouard Cheneau, Marco Castagna, Dong-Hun Cha, Laurent Leborgne, Lowell F Satler, Augusto D Pichard, Kenneth M Kent, Joseph Lindsay

Am J Cardiol | Published : 2004


We aimed to analyze periprocedural creatinine phosphokinase (CPK)-MB elevation in patients treated with intracoronary radiation therapy (IRT) for in-stent restenosis (ISR) to risk stratify these patients. The clinical significance of periprocedural CPK-MB elevation after IRT for ISR is unknown. An elevated CPK-MB has been associated with increased mortality after conventional angioplasty. We evaluated 1,326 patients who were enrolled in radiation trials for ISR at the Washington Hospital Center using gamma- and beta-emitters. Patients were analyzed according to degree of CPK-MB increase within 24 hours of the index IRT procedure (normal CPK-MB, CPK-MB 1 to 3 times the upper limit of normal, ..

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University of Melbourne Researchers