DELETIONS IN THE CONSTANT REGION LOCUS CAN ACCOUNT FOR SWITCHES IN IMMUNOGLOBULIN HEAVY-CHAIN EXPRESSION
S CORY, J JACKSON, JM ADAMS
Nature | MACMILLAN MAGAZINES LTD | Published : 1980
Deletions spanning portions of the heavy chain constant region (CH) locus in murine plasmacytomas are revealed by hybridization with cloned immunoglobulin DNA molecules. The pattern of deletions suggests that a lymphocyte clone switches expression of CH genes by successive deletions and that the probable CH gene order is 5' mu-gamma 3-gamma 1-gamma 2b-gamma 2a-alpha 3'.