Journal article

CHROMOSOME-8 BREAKPOINT FAR 3' OF THE C-MYC ONCOGENE IN A BURKITTS-LYMPHOMA 2-8 VARIANT TRANSLOCATION IS EQUIVALENT TO THE MURINE PVT-1 LOCUS

M GRAHAM, JM ADAMS

The EMBO Journal | OXFORD UNIV PRESS UNITED KINGDOM | Published : 1986

Abstract

The 2;8 variant translocation of human Burkitt's lymphomas is closely related cytogenetically to the t(6;15) of murine plasmacytomas; both involve a reciprocal exchange between the Ig kappa locus and a band region indistinguishable from that bearing the c-myc oncogene. To define their molecular relationship, we have compared cloned chromosome 8 DNA from the t(2;8) breakpoint in the human Burkitt's lymphoma JBL2 with cloned DNA from the murine pvt-1 locus, the major chromosome 15 breakpoint region in murine t(6;15). DNA sequencing and Southern blot analysis shows that these two regions are homologous. Thus the t(2;8) in JBL2 is the molecular equivalent of many murine t(6;15). The murine pvt-1..

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