Journal article
Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men
FS Kong, TW Rupasinghe, JA Simpson, LA Vodstrcil, CK Fairley, MJ McConville, JS Hocking
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Chlamydia is the most common bacterial sexually transmitted infection among men who have sex with men. Repeat infection following treatment with 1g azithromycin is common and treatment failure of up to 22% has been reported. This study measured the pharmacokinetics of azithromycin in rectal tissue in men following a single 1g dose to assess whether azithromycin reaches the rectal site in adequate concentrations to kill chlamydia. Ten healthy men took a single oral dose of 1g azithromycin and provided nine self-collected swabs and one blood sample over 14 days. Participant demographics, medications, sexual behaviour, treatment side effects, lubricant use and douching practices were recorded w..
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Funding Acknowledgements
The funding for this specific project was provided internally by the University of Melbourne through Professor Jane Hocking. Professor Jane Hocking led the project with FYSK (PhD student) and was involved in study design. FYSK is supported by an Australian Postgraduate Award, JSH and JAS are supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship. The funders of the Australian Postgraduate Award and the NHMRC Senior research Fellowship had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.