Journal article

Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

Vi Pham, Peta Burns, Anthony L Albiston, Holly R Yeatman, Leelee Ng, Shand Diwakarla, Siew Yeen Chai

PEPTIDES | ELSEVIER SCIENCE INC | Published : 2009

Abstract

During human pregnancy, a circulating form of insulin-regulated aminopeptidase (IRAP EC 3.4.11.3), often termed oxytocinase or placental leucine aminopeptidase (PLAP), is present in plasma. It is proposed that circulating IRAP plays an important role in regulating the circulating levels of oxytocin and/or vasopressin during pregnancy. We assessed the reproductive and maternal profile of global IRAP knock out mice. No differences in the reproductive profile were observed, with normal gestational period, litter size and parturition recorded. However, western blot analysis of pregnant mouse serum, failed to detect IRAP, a result which was confirmed by fluorimetric IRAP enzyme assay. A review of..

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University of Melbourne Researchers