LABAs: Pharmacology, Mechanisms and Interaction with Anti-Inflammatory Treatments

Abstract

This chapter contains sections titled: Galenical forms of LABAs: formulations, isomers, enantiomers, diasteriomers and salts Absolute and functional β2‐adrenoceptor selectivity Cellular organization of receptor clusters: functional structure of the β2‐adrenoceptor and mode of signalling Dimers and oligomers: homo‐ and heterodimerism/oligoism Pharmacogenomics of the β2‐adrenoceptor and adenylate cyclase polymorphism in relation to LABAs Understanding the ‘reassertion’ paradox, ‘exosites’ and relative speed of onset: the membrane diffusion microkinetic model of LABA action Regulation and desensitization Full versus partial agonism (pharmacological efficacy) Beta‐blockers not LABAs? Non‐recepto..