Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig.

Abstract

Inhibitors of platelet activating factor (PAF) and leukotriene synthesis or action are of interest as potential anti-asthmatic drugs. The present study outlines evidence suggesting an interaction between PAF and lipoxygenase products mediating increased airways responsiveness to histamine in vivo.