Journal article

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

Rikke Olesen, Selena Vigano, Thomas A Rasmussen, Ole S Sogaard, Zhengyu Ouyang, Maria Buzon, Arman Bashirova, Mary Carrington, Sarah Palmer, Christel R Brinkmann, Xu G Yu, Lars Ostergaard, Martin Tolstrup, Mathias Lichterfeld

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2015

Abstract

UNLABELLED: The pharmaceutical reactivation of dormant HIV-1 proviruses by histone deacetylase inhibitors (HDACi) represents a possible strategy to reduce the reservoir of HIV-1-infected cells in individuals treated with suppressive combination antiretroviral therapy (cART). However, the effects of such latency-reversing agents on the viral reservoir size are likely to be influenced by host immune responses. Here, we analyzed the immune factors associated with changes in proviral HIV-1 DNA levels during treatment with the potent HDACi panobinostat in a human clinical trial involving 15 cART-treated HIV-1-infected patients. We observed that the magnitude, breadth, and cytokine secretion profi..

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Grants

Awarded by Danish Strategic Research Council


Awarded by American Foundation for AIDS Research


Awarded by Clinical Scientist Development Award from the Doris Duke Charitable Foundation


Awarded by Danish Research Council


Awarded by Lundbeck Foundation


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by The Danish Strategic Research Council (grant 0603-00521B) and the American Foundation for AIDS Research (grant 108302-51-RGRL). M.L. is a recipient of the Clinical Scientist Development Award from the Doris Duke Charitable Foundation (grant number 2009034). O.S.S. is supported by a grant from the Danish Research Council (grant 12-133887) and a grant from the Lundbeck Foundation (grant R126-2012-12588).