Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir
Jesper F Hojen, Thomas A Rasmussen, Karen Lise D Andersen, Anni A Winckelmann, Rune R Laursen, Jesper D Gunst, Holger J Moller, Mayumi Fujita, Lars Ostergaard, Ole S Sogaard, Charles A Dinarello, Martin Tolstrup
MOLECULAR MEDICINE | SPRINGER | Published : 2015
Interleukin-37 (IL-37) is a recently identified cytokine with potent antiinflammatory and immunosuppressive functions. The objective of this study was to compare levels of IL-37 mRNA in immunological subgroups of chronic human immunodeficiency virus-1 (HIV-1)-infected individuals and noninfected controls, to determine IL-37's association with biomarkers of inflammation and reservoir size. This was a cross-sectional study. The HIV-1-infected patients were categorized in three subgroups depending on their combination antiretroviral therapy (cART) treatment status and CD4(+) T-cell count. Quantitative RT-PCR was used for the detection of IL-37 mRNA and HIV-1 DNA in peripheral blood mononuclear ..View full abstract
Awarded by Danish Research Council (FSS)
We would like to acknowledge all the participating patients who made this study possible. Special gratitude is also extended for Lene Svinth Johnke and Erik Hagen for their help and guidance in the lab, and to the medical laboratory assistants in Q-lab. The work was supported by The Danish Research Council (FSS) by grant 0602-02300B to M Tolstrup and by the Augustinusfonden, Familien Hede Nielsens Fund and Ulla og Mogens Folmer Andersens Fund to JF Hojen.