Journal article

Pneumococcal conjugate vaccination in persons with HIV: the effect of highly active antiretroviral therapy

Ole S Sogaard, Henrik C Schonheyder, Anne R Bukh, Zitta B Harboe, Thomas A Rasmussen, Lars Ostergaard, Nicolai Lohse



OBJECTIVE: Vaccination responses may be affected by concomitant use of highly active antiretroviral therapy (HAART). We aimed to determine HAART's impact on seven-valent pneumococcal conjugate (7vPnC) vaccine immunization with or without a Toll-like receptor 9 (TLR9) agonist adjuvant. DESIGN: Observational cohort study. METHODS: Adults with HIV were immunized with double doses of 7vPnC +/-1 mg CPG 7909, a TLR9 agonist and vaccine adjuvant, at 0 and 3 months, and 23-valent pneumococcal polysaccharide vaccine at 9 months. We measured IgG levels (ELISA) and opsonophagocytic activity (OPA) at months 0, 3, 4, 9, and 10. Persistent 7vPnC vaccine responders were defined as individuals with two-fold..

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Awarded by Coley Pharmaceutical Group

Funding Acknowledgements

The authors thank the participants for their involvement in the trial. They also thank the study nurses, Iben Loftheim and Inge Arbs, for their excellent work as trial site coordinators for the study; Coley Pharmaceutical Group (now part of Pfizer) for providing CPG 7909 for the study; Statens Serum Institut, Copenhagen and Flow Applications Inc., Illinois, USA for conducting the antibody analyses. Grant support by Aarhus University, the Augustinus Foundation, Scandinavian Society for Antimicrobial Chemotherapy, Danielsen's Foundation, AP Moeller's Foundation, Krista and Viggo Pedersen's Foundation, LF Foght's Foundation, KA Rohde, and Hustru's Foundation. Coley Pharmaceutical Group (now part of Pfizer) provided CPG 7909 for the study.