Journal article

CONJUGATES OF DENDRITIC CELLS AND MEMORY T-LYMPHOCYTES FROM SKIN FACILITATE PRODUCTIVE INFECTION WITH HIV-1

M POPE, MGH BETJES, N ROMANI, H HIRMAND, PU CAMERON, L HOFFMAN, S GEZELTER, G SCHULER, RM STEINMAN

CELL | CELL PRESS | Published : 1994

Abstract

Experimentally, a productive infection with HIV-1 requires that virus be administered to T cells that are activated by mitogens. We describe a productive milieu for HIV-1 within the confines of normal skin that does not require standard stimuli. The milieu consists of dendritic cells and T cells that emigrate from skin and produce distinctive stable, nonproliferating conjugates. These conjugates, upon exposure to each of seven different HIV-1 isolates, begin to release high levels of virus progeny within 4 days. Numerous infected syncytia, comprised of both dendritic and T cells, rapidly develop. We propose that conjugates of dendritic cells and T cells, as found in the external linings of o..

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University of Melbourne Researchers