Journal article

INFECTION AND APOPTOTIC CELL-DEATH OF CD4 T-CELLS DURING AN IMMUNE-RESPONSE TO HIV-1-PULSED DENDRITIC CELLS

PU CAMERON, M POPE, S GEZELTER, RM STEINMAN

AIDS RESEARCH AND HUMAN RETROVIRUSES | MARY ANN LIEBERT, INC | Published : 1994

Abstract

Interacting dendritic cells and helper CD4+ lymphocytes form a microenvironment that is permissive for HIV-1 replication. The virus need only be pulsed initially onto the dendritic cells, which then transfer HIV-1 to the lymphocytes that are responding to presented antigens or superantigens. We have pursued underlying mechanisms in this system, because it provides a model for the infection of antigen-reactive, primary T cells. Pulsing the T cells with HIV-1 results in much less of a subsequent infection than does pulsing the dendritic cells. The latter pulse occurs effectively in the presence of AZT. Direct examination of the interacting dendritic cells and T cells reveals extensive producti..

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University of Melbourne Researchers